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If Weed Makes You Extremely Nauseated, You’re Not Alone

In the fall of 2016, I became an egg donor. Following my hormonal treatments and egg retrieval, I began to experience unusual bouts of nausea. I didn’t think much of it at first, assuming it was an interim experience attributed to the hormonal changes my body was undergoing. I also found that cannabis, which I’d typically used to treat insomnia, provided temporary relief from the sick feeling in my stomach.

But as time went on, the rounds of nausea became prolonged and more severe. The smell and sight of food repelled me. I couldn’t bring myself to eat, sometimes for days on end, and I started to lose a lot of weight. I scheduled an appointment with a gastroenterologist to see if we could figure out what was going on.

I had noticed that the more I used cannabis to treat my nausea, the more sick I felt during the hours I wasn’t smoking. It seemed counterintuitive that cannabis might be playing a role in my sickness since it’s often recommended to alleviate nausea, but I felt compelled to tell the doctor I’d been smoking on a regular basis.

To my surprise, he told me that U.S. states that had legalized the medical or recreational use of cannabis, leading to an increase in cannabis usage, had also seen a significant rise in a condition known as cannabinoid hyperemesis syndrome (CHS). I was consistently experiencing prolonged nausea throughout the day—a common symptom of CHS. Because I smoked cannabis on a regular basis, the doctor believed my condition was, in fact, linked to cannabis use. My various test results came back normal, indicating he was likely right.

CHS is a puzzling condition occurring in long-term cannabis users. Common symptoms include extreme nausea, intractable vomiting, and abdominal pain. Many patients report finding relief by taking hot showers. It’s an unusual illness given that medical cannabis is often used to treat the nausea of cancer patients, for example. But it turns out that while cannabis is frequently effective against nausea and vomiting, it can also trigger it.

The symptoms of CHS sometimes take years to surface. The first course of action for cannabis users suffering from severe nausea and/or uncontrollable vomiting should be to cease cannabis use and see if symptoms subside within 2-3 days. I was advised to do this, and within two days, I was completely back to normal.

The cause of CHS is unknown. Because cannabis has complex chemical properties, it makes it difficult to pinpoint what leads to this seemingly paradoxical syndrome. Some research is focused on the body’s receptors which are affected by cannabis use. Heavy, frequent use is thought to deregulate receptors, causing the symptoms of CHS. Cannabis use, however, has been common for centuries in countries like India, and symptoms of CHS have only begun to be reported in the last couple of decades. In addition, there are no reports of CHS by chronic users in some regions, such as South Asia, at least not to the extent we see in the United States. This has led some doctors to be skeptical of the idea that cannabis itself is the problem, theorizing that additives may be the issue instead. In the case of Asia, however, lack of reports may also be due to the fact that weed remains strictly illegal in many of its largest countries, even as it gains acceptance in the West.

In my case, my fertility specialist believed CHS was directly linked to changes in my receptors caused by the hormones I was taking. I was scheduled to undergo a second round of egg donation, and he thought it was possible my receptors would revert back to normal afterward. Sure enough, following the second procedure, I no longer experienced the symptoms of CHS when using cannabis.

Cannabis use is increasing across the country as states not only legalize its recreational use, but also as it becomes increasingly seen as an effective alternative treatment to many commonly used pharmaceuticals, including opioids. Regardless of its cause, doctors expect to see a rise in cases of CHS coinciding with its increased use. Hospitals across the country have already seen more and more cases of CHS in states where weed has been legalized.

Cannabis was illegal in my state, so I was hesitant to tell the doctor I’d been using it. And, because of my unique situation, it would have been easy to blame my symptoms on recent hormone treatments, especially since cannabis provided temporary relief. But if I hadn’t been transparent, I would have continued to be sick. Be honest with your doctor if you use cannabis regularly and begin to exhibit these symptoms. Also be aware that many doctors may not yet be aware of CHS, and you may need to be the one to bring this possibility to their attention. It likely won’t remain under the radar for long, however. As cannabis continues to become more acceptable and accessible across the United States, we’ll need to work toward developing a better understanding of what causes CHS and how to prevent it.

Doctors are seeing an increasing number of cases of cannabinoid hyperemesis syndrome, which has symptoms cannabis is, ironically, often prescribed to treat.

Cannabis: the facts – Healthy body

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Cannabis (also known as marijuana, weed, pot, dope or grass) is the most widely used illegal drug in the UK.

The effects of cannabis can vary a lot from person to person. It can also vary depending on how much or how often it’s taken and what it contains.

Some examples include:

  • feeling chilled out, relaxed and happy
  • laughing more or become more talkative
  • feeling hunger pangs (“the munchies”)
  • feeling drowsy, tired or lethargic
  • feeling faint or sick
  • having problems with memory or concentrating
  • experiencing mild hallucinations
  • feeling confused, anxious or paranoid

Can you get addicted to cannabis?

It’s possible to get addicted to cannabis, especially people who are considered regular or heavy users.

If regular users stop taking cannabis, they may get withdrawal symptoms, such as feeling moody and irritable, feeling sick, difficulty sleeping, difficulty eating, sweating, shaking and diarrhoea.

Regularly smoking cannabis with tobacco also increases the risk of becoming addicted to nicotine and experiencing withdrawal symptoms from nicotine as well as cannabis if you cut down or give up.

Regularly using tobacco also increases the risk of tobacco-related diseases such as cancer and coronary heart disease.

Trying to give up cannabis?

If you need support with giving up cannabis:

  • see a GP
  • visit Frank’s Find support page
  • call Frank’s free drugs helpline on 0300 123 6600
  • see Drug addiction: where to get help
  • Marijuana Anonymous is a free self-help group. Its “12 step” programme involves stopping using marijuana with the help of regular face-to-face and online support groups. You can call them on 0300 124 0373 (callback service).

Cannabis and mental health

Regular cannabis use increases the risk of developing a psychotic illness, such as schizophrenia.

A psychotic illness is one where you have hallucinations (seeing things that are not really there) and delusions (believing things that are not really true).

The risk of developing a psychotic illness is higher in people who:

  • start using cannabis at a young age
  • smoke stronger types, such as skunk
  • smoke it regularly
  • use it for a long time
  • smoke cannabis and also have other risk factors for schizophrenia, such as a family history of the illness

Cannabis also increases the risk of a relapse in people who already have schizophrenia, and it can make psychotic symptoms worse.

Other risks of cannabis

Other risks of regularly using cannabis can include:

  • feeling wheezy or out of breath
  • developing an uncomfortable or painful cough
  • making symptoms of asthma worse in people with asthma
  • reduced ability to drive or operate machinery safely

If you drive while under the influence of cannabis, you’re more likely to be involved in an accident. This is one reason why drug driving, like drink driving, is illegal.

Cannabis and pregnancy

Cannabis use may affect fertility. Regular or heavy cannabis use has been linked to changes in the female menstrual cycle and lower sperm count, or lower sperm quality in men.

Using cannabis while pregnant may harm the unborn baby. Cannabis smoke contains many of the same harmful chemicals found in cigarette smoke.

Regularly smoking cannabis with tobacco increases the risk of a baby being born small or premature.

Cannabis has not been linked to birth defects, but research suggests that using cannabis regularly during pregnancy could affect a baby’s brain development as they get older.

Does cannabis have medicinal benefits?

Cannabis contains active ingredients called cannabinoids. 2 of these – tetrahydrocannabinol (THC) and cannabidiol (CBD) – are the active ingredients of a prescription drug called Sativex. This is used to relieve the pain of muscle spasms in multiple sclerosis.

Another cannabinoid drug, called Nabilone, is sometimes used to relieve sickness in people having chemotherapy for cancer.

Clinical trials are under way to test cannabis-based drugs for other conditions including cancer pain, the eye disease glaucoma, appetite loss in people with HIV or AIDS, and epilepsy in children.

Read the latest updates on cannabis, cannabinoids and cancer – the evidence so far on the Cancer Research UK website.

Page last reviewed: 3 December 2020
Next review due: 3 December 2023

Read about how cannabis (marijuana, weed, dope, pot) affects you, the risks and where to find help if you're trying to quit.