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The Ganja Guru сейчас здесь: วัดถ้ำเสือ Kanchanaburi.

HEMP SOAP FOR ACNE.

While some dermatologists are duking it out over whether or not THC triggers acne outbreaks, others are turning to a different part of the cannabis plant. While THC is known to increase oil production, CBD has the exact opposite effect. If you have really dry skin, chances are a little bump in our natural oils are a good thing. With acne, on the other hand, the body over-produces oil. This oil is known as sebum, and it’s excreted by the sebaceous glands in the skin. The term for the creation of sebum is “lipid synthesis.”

Back in 2010, one Hungarian scientist decided to put CBD to the test. Dr Tamas Biro isolated a group of skin cells and applied CBD. He wanted to see how the phytocannabinoid interacted with the natural endocannabinoids our own bodies produce. Endocannabinoids are a series of chemical compounds that help regulate hair growth, oil production, and immune response in the skin. Phytocannabinoids are the plant versions of these chemical compounds.

Turns out, endocannabinoids play a major role in determining how much sebum is produced in the skin. Too much of the endocannabinoid anandamide, our body’s own THC, leads to increased oil production. Not enough leads to dryness and conditions like eczema. When Brio applied non-psychoactive CBD to these skin cells, he noticed that anandamide decreased and oil production stopped. He explains:

“..[CBD] does not stimulate but inhibits lipid synthesis, especially if the lipid synthesis was previously upregulated, as for example in acne. It was very surprising, that a phytocannabinoid could prevent the action of the endocannabinoids. – Dr.Tamas Biro..”

This is good news for those with # acne . If your body is producing too much sebum, CBD calms the sebaceous glands down. If you have access to some CBD oil or CBD plants, it’s fairly easy to make your own medicated topicals at home. This recipe for cannabis-infused coconut oil will set you off on the right track. Of course, if coconut oil doesn’t work for you, you’ll want to pick a better medium.

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MEDICAL MARIJUANA THC/CBD AND COVID-19

THC and CBS and cannabis: Will connecting the two really lead to a viable treatment?

It’s far too early to come to any conclusions, so think about weed as playing a potential role in treatment.

The COVID-19 vaccine might be right around the corner, promising to put a less stressed face on 2021 than was the case in 2020, but it’s still a mighty wide turn. Commentary on the coronavirus-cannabis-connection that has ranged from wildly optimistic to ire-inducing will likely continue to be fodder for more study in the coming year as the world manages its way to a new normal.
A hospital in Israel is testing how cannabis can help coronavirus patients

•What does THC and CBD mean for COVID-19?

In a study published this past June, researchers at the University of South Carolina suggested that THC could help with treating symptoms associated with the coronavirus.
Specifically, the researchers explored what effect THC, previously shown to be a potent anti-inflammatory agent, may have Staphylococcus aureus bacteria (SEB) that leads to Acute Respiratory Syndrome (ARDS) in mice. The data seems to indicate that treating mice with THC post-SEB protects them “from SEB-mediated toxicity by inhibiting inflammation and ARDS.”

However, Dr. Prakash Nagarkatti, vice president of research at the university, recently suggested caution about celebrating too soon. “A high dose of cannabinoids may overtly suppress the immune response, which may make a normal individual more susceptible to COVID-19 infection,”

Dr. Nagarkatti explained to Cannabis Science and Technology. The Canadian Centre on Substance Use and Addiction seems to agree. Though more studies are needed to confirm THC effects on the immune competencies of both healthy and compromised individuals, “the large body of pre-clinical evidence supports the hypothesis that THC has a potential affect on immune functioning.”
A cytokine storm is a physiological reaction in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines.

While the coronavirus may have a high survival rate, ARDS has up to a 40% mortality rate. It is one of the leading causes which leads to death from COVID-19.
Research done at the University of South Carolina, Columbia was done on mice on the topic.

The treatment of mice with THC led to a 100% survival, decreased lung inflammation, and the suppression of cytokine storm.
In the mice model, 100% of the mice with ARDS induced by Staphylococcal enterotoxin B died. Throughout the course of the study, the researchers analyzed the mice for survival, ARDS, cytokine storm, and metabolome. According to the study, “The treatment of SEB-mediated ARDS mice with THC led to a 100% survival, decreased lung inflammation, and the suppression of cytokine storm.” In addition to other factors related to ARDS which were analyzed because of their similarity to human coronavirus symptoms, the study has built a convincing case for potential human trials. Either way, the subject deserves further consideration, even if it takes time to be integrated into therapies.

•Is a cytokine storm brewing?

Another study released in September, this time involving CBD, noted that clinical reports indicate the cytokine storm — the release of a large amount of the pro-inflammatory proteins, which can attack the lungs and overwhelm the immune system,associated with ARDS “is the leading cause of mortality in severe cases of some respiratory viral infections, including COVID-19.”

Citing CBD’s demonstrated anti-inflammatory effects on a number of conditions, the authors write, “it is logical to explore whether CBD can reduce the cytokine storm and treat ARDS.”

The findings indicate that CBD may play a potential protective role during ARDS that may prove helpful “by reducing the cytokine storm, protecting pulmonary tissues and re-establishing inflammatory homeostasis,”
Signs and symptoms of a cytokine storm include fever and chills, swelling of extremities, nausea and vomiting, headache, rash, cough, muscle and joint aches and shortness of breath. “COVID-19 is especially fatal when patients experience cytokine storms,” adds Cannabis Science and Technology. Study findings indicate that CBD may play a potential protective role during acute respiratory syndrom.

•CBD: Another anti-inflammatory agent

Apart from THC, CBD was already shown to have potential as a novel therapy for coronavirus. Interestingly, studies have also found CBD as a potential anti-inflammatory agent.
In the face of rising health risks, perhaps cannabis has only started giving in terms of its ability to combat modern ailments. In fact, CBD has also been found to combat superbugs.

•CBD was already shown to have potential as a novel therapy for coronavirus.

While certain legislation is slow on allowing the development of novel therapies, it’s unlikely that they will stop cropping up. With enough coverage, accuracy, and safety, cannabis is poised to win big in the world of pharmacology.

•Could high-CBD weed strains be part of a possible treatment?

Initial data from two University of Lethbridge biology professors, which has not been peer-reviewed, suggests 13 specific cannabis sativa extracts, all of which are high in CBD, “can modulate ACE2 expression in COVID-19 target tissues and down-regulate TMPRSS2 (protein).”
ACE2 receptors are proteins on the surface of many cell types that provide the entry point and allows the coronavirus to infect human cells. The virus then binds to ACE2 “prior to entry and infection of cells,” according to The Conversation.
Since the lower airways have more ACE2 receptors, “COVID-19 is more likely to go deeper than other viruses such as the common cold,” Health Europa reports.

The University of Lethbridge findings show “promise as an additional treatment for COVID-19,” and are “crucial for the future analysis of the effects of medical cannabis” on the coronavirus, Igor Kovalchuk and Olga Kovalchuk maintain in a statement.

The Kovalchuks point out the high-CBD strains, which are licensed to Sundial Growers, employed in the study “could be used to develop preventive treatments in the form of a mouthwash or throat gargle product for clinical and home use.” The research team went on to say, “Given the current dire and rapidly developing epidemiological situation, every possible therapeutic opportunity and avenue needs to be considered.”

Everyone should cool their jets about assuming cannabis is a treatment option. Consider both the short- and long-term possibilities. Some suggest it is critically important to consider not just acute care, but also conditions that could develop longer term as a result of COVID-19.

For example, Canadian start-up Akseera Pharma plans to manufacture CBD in India and begin clinical trials to test CBD as a potential therapy for irregular heartbeat which has a possible link to COVID-19.

For her part, Denise Vidot, an epidemiologist and assistant professor in the University of Miami’s School of Nursing and Health Studies, emphasizes the need to also remember how populations, including those already taking medicinal marijuana, may be affected by the coronavirus.

That is why Vidot and her team launched an electronic survey in April to obtain epidemiologic data on medical users. “The global qualifying conditions for medical cannabis, though not uniform, all include individuals with compromised immune systems and other chronic health conditions. Therefore, this is a population that we cannot forget about in our joint effort to ‘flatten the curve.’”

Cannabis market intelligence firm Prohibition Partners explains that “when the body has this overreacting immune system, such as in severe cases of COVID-19, the resulting inflammation can harm the body’s own tissues, such as lung tissue where respiratory failure can occur.”
The firm sees promise in a number of recent COVID-19/cannabis studies, but its search of databases such as ClinicalTrials.gov, the World Health Organization, the U.S. Food and Drug Administration (FDA) and news outlets suggests everyone should cool their jets about assuming cannabis is a treatment option… at least for now.

“Preliminary results in models of the disease in cell culture or animal models can never be assumed to translate to efficacy in human patients without further trials,” it adds.

•As always, vigilance is key

To avoid getting ahead of matters, vigilance with regard to good hygiene habits and protective measures is essential. Indeed, researchers at McMaster University in Hamilton, Ont. explored how cannabis sativa — long known to contain antibacterial cannabinoids — might do when set against methicillin-resistant Staphylococcus aureus (MRSA).
Published in ACS Infectious Disease, the mice study found that cannabigerol (CBG) prevented MRSA’s ability “to form biofilms, which are communities of microorganisms that attach to each other and to surfaces; and it destroyed preformed biofilms and cells resistant to antibiotics,” notes a university statement detailing the study findings.

HEMP SOAP FOR ACNE. While some dermatologists are duking it out over whether or not THC triggers acne outbreaks, others are turning to a different part…

The Reason You Should Use Castile Soap For Your Acne

Do you have a collection of cleansers claiming to diminish acne, or maybe a strict regimen of face treatments, but your pimples seem to be invincible? We’ve all been there, and with all the different products and companies offering cures to the red bumps on our faces, it’s harder than ever to know what to do. It seems like it might be time to go back to the basics with castile soap.

The bad news is that many anti-acne products are filled with skin irritants and toxins, but the good news is that there’s a simple alternative. Castile soap is a non-toxic, oil-based product that’s traditionally been crafted out of olive oil, but it can be made with hemp, avocado (for folks who didn’t get their avo toast fill), and coconut oils. It’s also earth-friendly and biodegradable. The natural product lathers up just like your chemical-filled soaps, but without the drawbacks (via Era Organics).

People have been using the stuff for thousands of years, so it’s got to be good right? It’s even worthy of a queen: Cleopatra apparently experienced a similar issue that we face today, and demanded a better cleansing product. In response, the Egyptians made her an early version of castile soap.

Castile soap can help sooth acne

Acne can be irritated by products with extreme pH levels. Our skin likes to have a pH of about 5.5, meaning it’s slightly acidic, but many cleansers totally throw that off (via Skin Care Rx). Castile soap is often considered a fairly neutral product on the pH scale, and is able to help balance the acidity in many skin types with its slight alkalinity. However, some castile products have been reported to leave skin feeling tight and dry leading to an overproduction of oil throughout the day (via Bustle). As with any product, it’s always safest to proceed with caution and act according to how your skin responds.

It can be tricky to find the right castile soap, but beware of products claiming to be natural while still including chemicals in their cleanser. A cult favorite of many oil-based soap fans is Dr. Bronners. It’s organic and easy to find, plus it has a whopping 18 uses, from laundry detergent to deodorant (via Best Advisor). If Dr. Bronners isn’t doing it for you, Kirk’s Original Hypoallergenic Castile soap might do the trick. It’s gentle enough for babies, and has been sold for almost a century as a non-toxic product. It’s definitely another great option for acne prone skin.

If your acne isn’t responding to common skincare options, an oil-based castile soap just might do the trick.

Do you have a collection of cleansers claiming to diminish acne, but your pimples seem to be invincible? With all the different products and companies offering cures to the red bumps on our faces, it's harder than ever to know what to do. It might be time to go back to the basics with castile soap.