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I wanted to drop by and get to know the neighbors.
Now the remaining three people, the man is called Zheng Xuan, a very cbd oil users handsome and handsome guy.
Let the factory run as cbd thc oil ideal ratio for inflammation soon as possible. Hao Ren said lightly.
No matter how good, he felt distressed. It s fine, calculate how much money you need and report it to the trazodone and marijuana finance department, and I ll approve it.
The two are so well dressed and even cbd oil users Cbd Oil And Tooth Pain the script is ready, it feels like a punch to the cotton.
Naturally, there is no need to work Does Cbd Pure Oil Help Inflammation cbd oil users every Nanotechnology Cbd renu health cbd reviews day to plant golden jade ears, but Hao Ren also Nanotechnology Cbd renu health cbd reviews has other arrangements for them, so it will not waste Cbd Gummies For Pain cbd oil users the labor.
Those two songs are good. When best cbd oil non marijuana for sleeping they are released, Ling how much cbd oil to take for sleep Fei s new song will probably be compared.
The farmer who was cooking in the stove heard this, thinking that it was Su Dongpo teaching him how to cook meat cooking with grass until the heart is fragrant , so he quickly put the green leaf oil pork and the straw that tied the meat into cbd oil users the pot to cook, It is called Dongpo elbow in later generations.
Hao Ren s eyes instantly brightened like a little sun, and he cbd oil users asked eagerly, What can I do He only had four words in his mind, I want to cultivate immortals That is to attract spiritual energy to be stored in the body through a special method, but it cbd and alcohol withdrawal will not be known until the host reaches the fourth level.
At how often can i take cbd gummies a young age, he has worked cbd oil users hard to achieve his current achievements, and he may be the richest man in Jiang Province in the future.
Although there is an online store, it is completely different from the physical store.
These people were a little anxious, for Cbd Gummies For Pain cbd oil users fear that Hao Ren would reject them.
Even if the entire province is cbd oil users Cbd Oil And Tooth Pain full, it cannot be compared with the whole country.
This is the cost of tens of millions of tickets.
Forget it, let s wait. Hao Ren sighed helplessly.
With that said, Xu Yujia handed the information about the Yinfeng International Hotel to Hao Ren, all of which had been sorted out.
What are you doing However, at the entrance of the corridor, they were stopped, and cbd oil users the security guard looked at them and asked Sandy Beach Hotel cbd oil users suspiciously.
Liu Nan Nanotechnology Cbd renu health cbd reviews smiled wryly A voice, a little helpless said.
There are so many people gold harvest cbd gummy who want to enter the company, and they all need to choose carefully.
Hao Ren did not participate in such a matter, but handed it over to Guo Lin.
The contracts of Cbd Gummies For Pain cbd oil users the three companies were delivered very quickly, or the director should make a trip in person, as well as the share transfer letter.
They don t come to school either. You have to remember to go back twice more.
The three took the bank card and put it away carefully.
However, this is not important anymore. Now the conditions have been opened to can cbd oil be prescribed renu health cbd reviews Cbd Oil Distributors Sean Connery this point, which cbd oil users is completely beyond their imagination.
In a quiet hotel suite, Jenny smiled and led Hao Ren to knock on the door.
If Mr. Hao Nanotechnology Cbd renu health cbd reviews cashes out, he can directly get a profit of 30 million yuan.
Can you reply to the lady later Jenny nodded.
I remember that my brother is an how long does it take smoking cbd oil to worke investment company, so you can open your own company Investment companies, investment companies, naturally invest their money in others, and then enjoy dividends.
It doesn t matter. If you don t want to sell cbd oil users it, forget renu health cbd reviews Cbd Oil Distributors Sean Connery it.
The next day, Hao Ren got up early, ate breakfast, and immediately cbd oil users took Da Niu and cbd oil users Cbd Oil And Tooth Pain hurried to the company.
Hao, you can take Does Cbd Pure Oil Help Inflammation cbd oil users a look at this investment contract.
Mr. Hao, don t worry, this one doesn t need a dissertation, it Nanotechnology Cbd renu health cbd reviews s just an honorary doctorate, which represents Cbd Gummies For Pain cbd oil users our how long to hold cbd oil under tongue reddit school s recognition of you.
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Chen Yao also chose a room. The next day, Hao Ren made an appointment with a cleaning company cbd oil users to come and clean the house, while he took Lu Sisi to buy some daily necessities.
Zhang awaken cbd oil Jinghong opened a bag of elf hearts to eat.
There are 200 yuan cbd oil for erectile dysfunction weed las vegas of red cbd oil users Cbd Oil And Tooth Pain envelopes in total.
It has been a week since Hao Ren s strike up dietary supplement investment in Dragon renu health cbd reviews Cbd Oil Distributors Sean Connery Fruit.
By the way, since you agree, I think that our company will be opened in Modu, which is the bridgehead in China and the most prosperous city, and the import and export of products is also cbd oil users the most convenient.
Guo Lin nodded, Does Cbd Pure Oil Help Inflammation cbd oil users and then said nothing. After the other party left, Guo Lin asked Hao Ren to cbd oil users go to a massage club, which is a membership system and does not accept individual customers.
Duan Hong said lightly. Okay, then you can pay whatever you want.
I thought my brother would beat 10 , but I didn t expect my brother to cbd oil users give me 30.
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This is another epoch making product of our company, and I plan to embed it in the movie, cbd oil users said Hao Ren.
Hao Ren Nanotechnology Cbd renu health cbd reviews said with a smile, and finally looked at Yi Xueming.
Lu Yuan thought excitedly, Or, for a salary of 10 million, there will be 300 million in the box office, which is divided into 1.
Xu cbd oil users Jing naturally saw them and nodded vaguely, but Seeing Hao Ren, his face froze.
Hao Ren was stunned, as expected of being a top tier top notch person.
She nodded slightly to Hao Ren. To be honest, she was also full of gratitude towards Hao Ren.
If that s the case, then it s purely based on ability.
They said it was inside, but there was actually a cbd oil users Cbd Oil And Tooth Pain layer of glass separating the production machines from the aisles of the workshop.
There are also broadcast expenses for concerts, advertising expenses Sandy Beach Hotel cbd oil users for sponsors, etc.
Hearing this, Hao Ren s eyes flashed, but he didn t say anything.
Looking at the three of Chen Hongbing, they cbd oil massage hand and stone wanted to tear them apart.
It wasn t cbd oil users Hao Ren s debt, so renu health cbd reviews Cbd Oil Distributors Sean Connery why should he be responsible for himself He cbd oil users was a businessman, not Does Cbd Pure Oil Help Inflammation cbd oil users a philanthropist.
Guo Lin said with a headache, this is a hot potato, but his relationship with the government wants him to take over, but with cbd oil users 50 million event sponsorship, he is really I don cbd oil users t cbd oil users cbd oil users want to take it out.
Hao Ren s investment showed that Lu Yuan was not a poor Cbd Gummies For Pain cbd oil users man and had a little background, at least not those pheasant directors who wanted money but had no money.
Hao Ren made a small suggestion. Lu Sisi s eyes lit up and nodded quickly.
They dared to refute, that is, Nanotechnology Cbd renu health cbd reviews they didn t want their future.
Hao Ren said indifferently. Of course, I know you don t have any money, so if you need it, I know some construction workers, or some factories, and I can help you cbd oil users Cbd Oil And Tooth Pain introduce some jobs.
Mr. Zhou, you re here so early. Hao Ren said with a smile when he saw him, while Daniel found a chair and sat cbd oil users there quietly, playing with his cbd oil users phone.
After listening to Hao Ren, he thought about it carefully, and suddenly said, The God of Cooking competition is still going on.
Hao Ren said immediately. When the overall effect comes out, go to Mr.
Hao Ren joked. Is it more beautiful or uglier Xiao Hongyu asked with a half smile.
Unexpectedly, when he said this, everyone agreed.
Jiang Xiaoya took the drink and nodded, It s alright, the diet is cbd oil users Cbd Oil And Tooth Pain what does drinking cbd oil feel like not much cbd oil users Cbd Oil And Tooth Pain different from ours, but the climate is much warmer than ours, we are still wearing coats, and we are already here.
If you are an ordinary entrepreneur, no one will bother you.
Wang Yan looked at everyone with a smile. Everyone has the qualifications to participate, and the lottery method is fair and just.
He asked, Is this playing cards Fighting the landlord, Mr.
From his position, he could even clearly see the expressions on Xu Jing s face.
Hao Ren said more. The next day, Hao Ren took Lu Sisi to Yanjing by plane, passed Zhou Feng, and arrived at cbd oil users Sandy Beach Hotel cbd oil users Shao Yizhi s home.
In his Does Cbd Pure Oil Help Inflammation cbd oil users view, the intertwined connections are more precious than tens of millions.
However, sweet cbd oil users Cbd Oil And Tooth Pain car beauty, this is enough to make any man sink.
Hao Ren looked at each other with admiration.
She felt Hao Ren s question It was a little strange, and he couldn t help but look at the Sandy Beach Hotel cbd oil users Chinese man with glasses beside him.
Lawyer Zhou has a good eloquence. Hao Ren couldn t help but praise him, If renu health cbd reviews Cbd Oil Distributors Sean Connery you were in China, I would definitely dig you into our company.
This resentment was naturally given to Chen Sandy Beach Hotel cbd oil users Yao, and could only be vented on cbd oil users these two liars, and the other security guards.
Both of them are confident. In this place in the magic capital, they are not considered top notch, but they are also considered to cbd oil users be cbd oil users the school cbd oil users beauty level.
However, there is no way to how many mg in 1 drop of 1000 mg cbd oil do this, but to wait until the independent products are produced.
Soon, a person came out, frowned and said, Who is Hao Ren Hao Ren stood up, looked at the other party, and nodded, I am.
What should you do and is cbd oil legal in indiana in 2022 how to do it You are the master of the little things.
Let s buy a good car, and we ll have a face in the future, so we how much cbd water soluble oil should a 200 pound man consume won t be cbd oil users underestimated.
Thinking of cbd oil users the profit contained in it, Hao Ren cbd gummies miami fl felt a little excited.
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In fact, he could have bought it for the other party, but Hao Ren was more principled.
They have also thought of some ways, discounts, gifts, and even cbd oil users cbd oil users invite chefs cbd oil users from Michelin restaurants to engage in Sandy Beach Hotel cbd oil users gourmet activities and lucky draws
Life is more precious. Hao Ren opened his mouth cbd oil users and corrected Nanotechnology Cbd renu health cbd reviews it.
Director Zhang, when are we going to see Xu Jing Hao Ren asked.
After walking out of the cbd oil users coffee shop and sitting Sandy Beach Hotel cbd oil users in Hao is there a better time to take your daily dose of cbd oil Ren s co pilot, Liu Mengxue was a little embarrassed and looked around curiously.
This product has been accepted by many people in the upper class.
This is a low quality company. If it cbd oil users is replaced by a high quality company like Hao Ren, let alone 30 the introduction of cbd oil in usa million, they can give away without blinking an eye.
Glancing at Xu Sheng next to him, Hao Ren smiled, took a box, threw it to the other party, and scolded, cbd oil without thc pregnancy It s cheap for how to use weed oil you.
Your supermarket Cbd Gummies For Pain cbd oil users can sell Shinhwa s products, which amazes me.
Meng Liang thought of this, looked at his father, and sighed in his heart, Jiang is still old and hot, my father can think so much at once, and he still has a long way to go
Hao Ren nodded, Copy the video here, you can bring it back to your team for reference.
Haha, brother, you are really happy, your cbd oil users girlfriend is how do i use hemp oil beautiful, and the younger sister is not bad.
However, when cbd oil users the how big of industry is cbd oil laundry detergent is put in, the gap comes out.
The operation of fruits and vegetables. also came to the renu health cbd reviews Cbd Oil Distributors Sean Connery scene.
Our niece works here, and cbd oil users I ask you is it legal to order cbd oil online to be accommodating, brother.
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At ten o clock in the morning on the third day, the signing ceremony opened.
Fortunately, the sound insulation of the house is good, otherwise, everyone would not have Cbd Gummies For Pain cbd oil users to sleep.
As a medical staff, how could he say that to a patient.
At the end of the month, the finance department of Shinhwa Company will naturally transfer the money to cbd oil users their account.
Several beauties, are you from the Shinhwa cbd oil users cbd oil users Company Su Xi looked at Hao Yue, Dai Shixuan and the cbd oil users others, and asked in a gentle tone.
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In the conference room, Hao Ren looked at the management of the first factory and said with a smile, Don t cbd oil users be nervous, everyone, I just stopped by to see.
Tears are not for you, but for others
Lu Si was about to say something, but was interrupted by Chen Yao, and cbd oil users said with a chuckle, Hao Ren is very good to me, I am not wronged, a real wife who may be the richest man in the country in the future, some others Where do you need to pay attention to small flaws Lu Sisi was silent, Nanotechnology Cbd renu health cbd reviews feeling a does cbd make you poop little uncomfortable.
A man said with a smile, shaking extracting oil from weed his Cbd Gummies For Pain cbd oil users mobile phone, There is nothing on renu health cbd reviews the mobile phone now, it has long been spread.
You can give me a price. If it is suitable, I can virginia cbd make a decision cbd oil users today.
Thank you, Mr. Hao, I will definitely live up to my expectations.
Poor school parents. Haha, they are all your juniors and juniors anyway.
With common interests, if Hao Ren has any products in the future, the first profit will definitely be Run.
After thinking about it carefully, he said slowly, If it 1000percent cbd oil in kenty were me, I would use it instead
I can t get out of the car. Hearing this, a group of people hurriedly made way.
Only when you actually eat the products from Hao Ren s shop can cbd oil users you really feel the sky defying effect, and cbd oil users even if you don t care how much sunsoil cbd oil dosage you spend, you should stick to it.
Chen Yao shook her head helplessly, You girl, it s been more than a month since cbd oil nashville lebanon pike you left.
Hearing this, the corner of Zhou Yuan s mouth curved, and he smiled lightly, A passionate youth It s a joke, he can go from nothing to where he is in a short period of time.
The head of the cbd oil users commercial Sandy Beach Hotel cbd oil users bank said with a smile, Actually, when it comes to corporate business, our China Merchants Bank is more professional
Jiang Xiaoya and Qin Wen were not surprised at all.
Uncle Jiang, you really look down on me, Don t worry, I will definitely live up to your expectations, by the way, the construction of Jinyusui s configuration base will start Sandy Beach Hotel cbd oil users after the new year, and Sandy Beach Hotel cbd oil users the profit share from the sale will be paid to the finance on time.
After all, it s just for sale in expensive supermarkets and takes up some space.
Lu Chengjun said cbd oil users in a deep voice, cbd oil users since things are cbd oil users Cbd Oil Produced In Missouri in his hands, they must be of maximum value, which has nothing to do with character.
It was just some stock that could be exchanged for cooperation with Hao Ren, and the people on the board cbd oil users of directors would definitely agree.
That s for the little sister. I ll put it aside.
Therefore, after weighing it up, Zhang Jinghong quickly responded, No problem, you can send me the project information and I will arrange it.
Are you all from the same major Hao Ren asked curiously.
So, Hao Ren said indifferently, Don t disturb me cbd oil users if you re okay.
There are cbd oil users still 2,000 yuan per month, so you can work overtime to earn more money.
At that time, a few people had already given up, and even cbd oil users if Sandy Beach Hotel cbd oil users the price was increased, they would all go up one million to one million.
Hao Ren smiled, It s about the same. At last, it was a bit of a benefit.
Moreover, what Zhou Yuan knew even more was that Hao Ren s company s terrifying profitability was not too much at present, but in the next two years, the market value of their entire company might not be comparable to Hao Ren s.
Hao Ren also notified Zhou Mo and the others and asked them to come over at three o clock in the afternoon.
They have their own R D teams, and they are all high paid researchers from home and abroad.
I recently got in touch with Director Zhang, and now the audition is going on in the early stage of the Chef King Competition.
cbd oil users Hao Ren also took renu health cbd reviews a look, and then directly signed the contract.
CBD: A User’s Guide
CBD is seemingly everywhere and in everything, from CBD-infused creams to CBD-infused oils, tinctures, gummies, juices, and lollipops. But does it work, and is it safe? We’ve got your questions covered.
I n case you haven’t heard, CBD is a cure for whatever ails you, from insomnia and inflammation to pandemic angst. Or at least that’s what retailers, supermarkets, mini-marts, beauty stores, and coffee and smoothie shops across America would have you believe. There are CBD-infused creams. CBD-infused oils. CBD-infused tinctures, gummies, juices, lollipops, lattes, nutritional supplements, and even a CBD oil–infused pillow! What’s next, CBD-infused tampons? (Actually, that already exists. Really.)
According to the Brightfield Group, a market research firm, CBD sales were estimated to exceed $4 billion at the end of 2021, and by 2025, the industry’s total market value could reach a whopping $16 billion.
Put that in your pipe and smoke it.
But does CBD work?
That’s a question worthy of a Talmudic scholar, because the CBD world is complicated.
Some believe that it may have an important role to play in certain health outcomes.
Raphael Mechoulam, PhD, a professor of medicinal chemistry at Hebrew University in Jerusalem, Israel, has been studying the health benefits of cannabis and CBD since the early 1960s. Long considered the grandfather of cannabis research, Dr. Mechoulam and his team developed a process for synthesizing certain acids found in the cannabis plant. These acids — otherwise known as cannabidiolic acid (CBDA), and a methylated version of CBDA (CBDA-ME) — have been since studied for a variety of purposes, and might ultimately be used to develop new drugs for everything from arthritis and anxiety to inflammatory bowel disease and psoriasis.
Others believe CBD is unproven and risky.
The U.S. Food and Drug Administration (FDA) continues to investigate its potential harms, noting that while it recognizes the potential opportunity that cannabis-derived compounds (like CBD) can offer, it remains concerned about CBD products being marketed as supplements. (According to the FDA, THC and CBD products do not fit the definition of a dietary supplement.)
“FDA is aware that some companies are marketing products containing cannabis and cannabis-derived compounds in ways that violate the Federal Food, Drug, and Cosmetic Act (FD&C Act), and that may put the health and safety of consumers at risk,” the Agency wrote in its 2021 update, noting that it’s illegal to market CBD by adding it to a food or labeling it as a dietary supplement.
Among a number of problems with CBD, the FDA says, is that it can cause liver damage and diarrhea, it may impact the metabolism of other drugs, and it may cause male reproductive toxicity in humans, as has been found in animal studies.
Still, many consumers continue to believe CBD’s potential benefits. A report (PDF), also from the Brightfield Group, that analyzed 2,400 members of an online community of medical cannabis users found that 59 percent of CBD users say they use it for insomnia and 66 percent for anxiety, while 44 percent have taken it for depression and 49 percent for joint pain and inflammation.
With so much CBD noise out there, we’re feeling a little overwhelmed and confused about CBD. We want to know the real deal. For starters, is CBD the same as cannabis? Should we spend our hard-earned money on the stuff, or is it a scam? Is there any science to back up the claims that CBD is helping people sleep better, feel better, look better, or be an all-around better human? If so, is that in the form of CBD oil, tinctures, lotions, or should we vape it? But wait — isn’t vaping bad for you?
Relax. We’ve got you covered. Herewith, the real scoop on CBD. (Buyer beware: Abbreviations ensue.)
Common Questions & Answers
Endocannabinoids are molecules produced by the body to maintain homeostasis — stability — in response to changes in the environment. The endocannabinoid system interacts with all of the major systems and organs in the body to enable and restore optimal functioning.
The word “cannabinoid” usually refers to a chemical found in the cannabis (marijuana or hemp) plant. “Endo,” in this context, refers to substances produced inside the body. Endocannabinoids are, in effect, the body’s own source of cannabis-like substances.
CBD and THC are plant cannabinoids, which operate much as endocannabinoids do, by attaching to certain receptors on the outsides of cells and altering the behavior of those cells or the bodily systems they are a part of.
Cannabinoids and endocannabinoids can affect pain perception, memory, mood, appetite, and many other bodily systems. The endocannabinoid system regulates the release of other neurotransmitters — that’s how it maintains homeostasis — and helps the body heal from any damage it sustains. Plant cannabinoids can similarly enhance feelings of well-being, but they can have undesirable side effects as well, particularly in young people.
Research suggests that endocannabinoids can be boosted by certain foods, such as those containing essential fatty acids, chocolate, herbs, spices, and teas, as well as by stress-reducing activities.
CBD: The Good, the Bad, and the Confusing
Before we get too much into the, er, weeds, it’s important to understand what CBD is and where it comes from.
Cannabis refers to a group of three varieties of marijuana plants with psychoactive properties: Cannabis sativa, Cannabis indica, and Cannabis ruderalis.
Cannabis contains more than 400 compounds, known as cannabinoids (pronounced keh-NAB-eh-noyd). The most well-known and researched are cannabidiol (CBD), and delta-9-tetrahydrocannabidiol (THC). Other lesser known components — THCA, CBN, CBC, and CBG — play different roles and have different effects in the body. (See our CBD glossary for details.)
The component in cannabis that is linked to its intoxicating effects (in other words, the “high,”) is THC. Conversely, CBD won’t get you high. Depending on your goals, this is either a good or a bad thing.
“Hemp” (which incidentally, is considered part of the CBD family) refers to non-intoxicating varieties that are high fiber or high seed-yielding and often used for rope, clothing, or sails. (Cocktail party fact: “The word ‘canvas’ comes from ‘cannabis,’ as it was made from cannabis fiber varietals,” says Will Kleidon, the CEO of Ojai Energetics in Ojai, California..)
In the United States, the legal definition of hemp is any cannabis plant whose delta-9 THC is below 0.3 percent.
What’s the Endocannabinoid System and How Does It Work?
The endocannabinoid system (ECS) is a biological system first described in the 1990s, and it plays a big role in brain, endocrine, and immune function. Its main role, however, is to maintain homeostasis, the internal biological balancing mechanism of the brain and body.
Two main elements of the system are endocannabinoid receptors, classified as CB1 and CB2. The body makes its own cannabinoids, known as endocannabinoids, that can act upon these receptors. But other varieties of cannabinoids, such as CBD, can interact with them, too.
What Are Cannabinoid Receptors?
Cannabinoid receptors are laced throughout the body, brain, and nerves.
- Cannabinoid 1 (CB1) Receptors Most of these are in the central nervous system, especially neurons (nerve cells) in the brain.
- Cannabinoid 2 (CB2) Receptors These are located mainly on immune cells but are also found in the central nervous system.
Both receptor types are activated by cannabinoids, which can be generated naturally inside the body (known as endocannabinoids) or can be introduced through a form of cannabis.
What’s the ‘Entourage Effect’?
The entourage effect refers to a theory that the whole is more effective than each part — or that the various compounds of the cannabis plant work best synergistically.
“It’s the theory that the cannabinoids, flavonoids, terpenes, and fatty acids all work together like an orchestra, in which all the instruments complement each other so you get the maximum effect of the plant,” says the cannabis researcher Monica Taing, PharmD. “CBD by itself can be a pain reliever, and THC can be a pain reliever by itself, but when combined, they work better for pain relief. That’s the entourage or ensemble effect.”
Now that that’s out of the way, let’s get into the nitty-gritty.
What Are the Legal Implications of Using CBD?
The legality of CBD is confusing.
In 2018, the Agriculture Improvement Act of 2018 (aka that year’s Farm Bill), legalized CBD derived from hemp — with the important caveat that it could only contain 0.3 percent of THC by dry weight, to be grown legally. This type of CBD is legal in 47 U.S. states with some restrictions, but totally illegal in Idaho, South Dakota, and Mississippi. Plants with more than 0.3 percent of THC are considered marijuana, which is legal for recreational use in 19 states, Washington, DC, and Guam.
Despite state laws legalizing the sale of cannabis for recreational or medicinal use, the Drug Enforcement Administration (DEA) (PDF) still classifies it as a Schedule 1 drug: “substances or chemicals [that] are defined as drugs with no currently accepted medical use and a high potential for abuse.” So, while marijuana is illegal on a federal level, states have different laws regarding marijuana and CBD.
Only one cannabis-derived drug product has been FDA approved: cannabidiol sold under the brand name Epidiolex, which contains a purified form of high-dose CBD to treat a rare, hard-to-treat form of epilepsy in children ages 1 and up.
How Do I Find Safe CBD Products? How Do I Know What I’m Getting?
Short answer: You often don’t.
The situation is not unlike that of dietary supplements, except for in the case of supplements, the FDA has defined a very clear set of restrictions — and the Federal Trade Commission, strict reinforcement of health claims. While the FDA has sent warning letters to certain companies selling CBD products, many products slip under the radar. In addition, state and Federal CBD regulations are at odds, so oversight can be difficult. What’s more, every state where medical or recreational marijuana is legal has its own testing rules and regulations, so something that passes muster in Massachusetts might not in California.
People often buy their products online or at the local drugstore or gas station, meaning that they often don’t know what they’re getting.
“Some CBD products don’t contain CBD, but they contain THC and heavy metals, so we need strong regulations,” says Dr. Taing. Indeed, as of May 21, 2022, poison control centers have managed 2,652 cases related to CBD, per the American Association of Poison Control Centers.
Some people have failed drug tests because they’ve unwittingly taken THC that was in a product that was supposed to contain only CBD. A study published in the Journal of the American Medical Association (JAMA) in November 2017 found that 21 percent of CBD products derived from hemp and sold online contained THC, even though THC wasn’t listed on the packaging.
A more recent study in JAMA Psychiatry showed that even a high-quality, high-potency cannabidiol product labeled as carrying as much as tenfold less than the legal limits of THC permissible under law might still result in positive urine drug tests.
Findings from another study, published June 2022 in the Journal of Cannabis Research, showed that of the 80 products evaluated, 37 contained CBD concentrations that were at least 10 percent higher or lower than the concentration listed on the label: 12 products contained less than 90 of what was listed, while 25 products contained more than 110 percent.
Even more worrisome, a study published in January 2019 in Forensic Science International examined nine liquids that were advertised as 100 percent natural CBD extract and found they contained potentially problematic compounds. One contained dextromethorphan, which is used in over-the-counter cough medication and is considered addictive when abused. Four others had a synthetic cannabinoid that can cause, among other things, anxiety, psychosis, and even death.
“As with any other product you would ingest, you have to be smart,” says Jahan Marcu, PhD, the editor in chief of the American Journal of Endocannabinoid Medicine, and the cofounder and chief science officer at the International Research Center on Cannabis and Mental Health.
What’s more, he says, every product should have a certificate of analysis, or COA — a document generated by a laboratory certifying its legitimacy and also listing the ingredients.
The Mayo Clinic uses the following checklist to identify high-quality products, as described in a 2019 issue of Mayo Clinic Proceedings:
- Does it meet the following quality standards? These include Current Good Manufacturing Practices (CGMP) certification from the FDA; European Union (EU), Australian (AUS), or Canadian (CFIA) organic certification; National Science Foundation (NSF) International certification.
- Does the company have an independent adverse event reporting program?
- Is the product certified organic or eco-farmed?
- Have their products been laboratory tested by batch to confirm tetrahydrocannabinol levels below 0.3 percent and no pesticides or heavy metals?
For more information, Project CBD, Certified Kind, Clean Green, and WeedMaps offer information on dispensaries, cannabis products, and brands.
Does It Matter if the CBD Is Organic?
In theory, yes, because without an organic label, there’s a potential for ingesting pesticides and chemical fertilizers. If you have a COA, then you’ll know what’s in the product.
But here’s the rub: Organic products are regulated by the U.S. Department of Agriculture (USDA), which is a federal agency. Since cannabis is considered a Schedule 1 drug, technically, medical cannabis couldn’t be designated as “organic,” unless it’s made from hemp.
In May 2018, Palmetto Grow became the first company to have USDA Organic certification for hemp flower and seed. Since then, other organic growers have joined the market. You can find a list of some of the best organic CBD products from EcoWatch and The Honest Consumer.