What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. We explore CBD for pain and inflammation, CBD's function in suffering dogs, the best CBD for dog joint pain, and the safety of CBD in conjunction with traditional pain medications.
Can my Dog take CBD Oil While Taking Other Medications?
With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.
In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.
Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.
Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.
CBD can alter the way your dog processes certain medications
Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.
CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.
There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.
You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.
Benefits of CBD Oil for Dogs
Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.
A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)
The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.
FDA & CBD
The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.
Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.
Blood Pressure and CBD Oil
High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.
A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:
The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”
CBD Oil Interacts with Anti-Seizure Meds
A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.
Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.
Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.
Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.
Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”
The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “
A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”
CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.
When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.
Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.
NSAIDs and Corticosteroids
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.
That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.
Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.
NSAID’S include the following:
Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.
Common corticosteroids include the following:
The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?
CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.
CBD for Dog Pain
Seeing your dog in pain is not a pleasant experience, and of course, you want to help them in any way you can.
Could CBD for dog pain be a natural alternative to traditional drugs like Buprenorphine, Carprofen, Prednisone, or even opioids like Tramadol and Trazadone?
We explore CBD for pain and inflammation, CBD’s function in suffering dogs, the best CBD for dog joint pain, and the safety of CBD in conjunction with traditional pain medications.
Table Of Contents
- Does CBD work for dogs with pain and inflammation?
- How CBD works to regulate pain and inflammation in dogs
- Acute Pain
- Chronic Pain
- Best CBD for dog joint pain
- Can dogs take CBD with other pain medications?
Does CBD work for dogs with pain and inflammation?
If you have spent time reading our blogs, you are aware of clinical trials and studies about managing canine pain with CBD.
CBD shows properties associated with pain reduction in the mammal ECS (endocannabinoid system), but further studies are needed to understand it fully.
Here are some highlights from available trials, studies, and quotes showing CBD’s potential as a pain reliever.
A Cornell study found that researchers could increase dogs’ comfort levels from arthritic pain using 2 mg/kg of CBD oil twice a day. The results showed a noteworthy decrease in pain and increased activity at weeks two and four of treatment compared to week zero and the placebo group.
Another study by Baylor University found that dogs with osteoarthritis had significantly reduced pain when treated with CBD.
Mark Verdino, MD, stated CBD seems to reduce the reactions of low-level pain stimuli such as mild arthritis.
Fortunately, the sparse trials and studies on CBD do not limit our ability to make good decisions when giving our dogs CBD. The human and canine ECSs function the same way. The similarities open a window into what may be happening in the canine ECS through human studies.
Dr. Gary Richter said there are some differences in how cannabis affects humans and pets, but CBD’s benefits are similar in both species.
Human trials have shown CBD treatment significantly reduced pain. Chris Meletis, ND (naturopathic doctor), discussed a study in which seven kidney transplant patients suffering from pain were given an initial dose of up to 100 mg/day of CBD. Two subjects experienced complete resolution of pain, four had a partial improvement in the first 15 days, and one person did not improve.